Mohebat Vali; Alireza Mirahmadizadeh; Zahra Maleki; Fatemeh Goudarzi; Arefe Abedinzade; Haleh Ghaem
Abstract
Backgrounds: Given the novelty of COVID-19, reviewing diagnostic methods can be of great help to community health policymakers. Considering the importance of diagnosing COVID-19 and the need for reducing the number of false positive and false negative cases that appear to be different in various ...
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Backgrounds: Given the novelty of COVID-19, reviewing diagnostic methods can be of great help to community health policymakers. Considering the importance of diagnosing COVID-19 and the need for reducing the number of false positive and false negative cases that appear to be different in various diagnostic methods, this systematic review aimed at comparison of PCR test accuracy with laboratory data and CT SCAN in COVID-19.
Methods: In this systematic review, EMBASE (Elsevier, 2018), MEDLINE (National Library of
Medicine, 2018), Scopus, ProQuest, Web of Science (Clarivate Analytics, 2018b), and Google Scholar
data bases were searched for the studies published prior to 3 April 2020. Based on the inclusion criteria, 20 out of 859 primarily screened studies were finally assessed.
Results: The results indicated that the laboratory diagnosis of viral nucleic acid could have false-negative results, and serological testing of virus-specific IgG and IgM antibodies should be used as an option for diagnosis. Moreover, chest Computerized Tomography (CT) was found to be more sensitive in comparison toReverse Transcription Polymerase Chain Reaction (RT-PCR) (98% vs. 71%). Hence, the articles offered the combined use of chest CT, SARS-CoV-2 RT-PCR, and multi-plex PCR.
Conclusions: Follow-up RT-PCR and chest CT are necessary in COVID-19. In addition, serological testing of virus-specific IgG and IgM antibodies along with laboratory diagnosis of viral nucleic acid can lead to the highly sensitive and accurate diagnosis. Moreover, Enzyme-Linked Immunosorbent Assay (ELISA) is one of the cost-effective methods in epidemic conditions in low- and middle-income countries.
Mohebat Vali; Alireza Mirahmadizadeh; Zahra Maleki; Fatemeh Goudarzi; Arefe Abedinzade; Haleh Ghaem
Abstract
Background: The new Corona virus disease (COVID-19) appeared in Wuhan, China in December 2019. Methods, such as quarantine, isolation, and social distancing, if implemented properly, can help prevent the transmission of the disease. This study aimed to examine the effects of quarantine, isolation, and ...
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Background: The new Corona virus disease (COVID-19) appeared in Wuhan, China in December 2019. Methods, such as quarantine, isolation, and social distancing, if implemented properly, can help prevent the transmission of the disease. This study aimed to examine the effects of quarantine, isolation, and social distancing on the prevention of COVID-19.
Methods: In this systematic review, EMBASE (Elsevier, 2018), MEDLINE (National Library of Medicine, 2018), Scopus, ProQuest, Web of Science (Clarivate Analytics, 2018b), and Google Scholar databases were searched for the studies published prior to 10 April 2020. The search and data extraction were conducted by two authors and to check and control the quality of the articles, we used the Newcastle-Ottawa checklist.
Results: Based on the inclusion criteria, 24 out of the 768 primarily screened studies were finally assessed.
Studies showed that the short-term negative psychological effects of quarantine included frustration, boredom, anger, and confusion. Nonetheless, extending the adult quarantine period to 18-21 days could be effective in preventing the spread of the virus and controlling the disease. Moreover, the decision to control the people’s travels through restrictions on freedom of movement must be balanced regarding the estimated epidemiological impact and the expected economic outcome.
Conclusions: Although isolation, quarantine, and social distancing all have challenges, they are very useful methods for controlling the disease, which can be best used by knowing their duration of implementation.
